Emergent properties of memory networks with E-I assemblies
Abstract: Animals constantly sample information from the external world, and memorizing some of it is essential for adaptive behavior. Classical views suggest that memories are stored in assemblies of excitatory neurons and retrieved through attractor dynamics. However, increasing evidence indicates that during learning, groups of both excitatory (E) and inhibitory (I) neurons become strongly interconnected, […]
Other kinds of connectomes: wireless networks and behavioural states
Abstract: Efforts are ongoing to build and map synaptic wiring diagrams, or connectomes, to understand the neural basis of brain function. However, chemical synapses represent only one type of functionally important signalling interaction between neurons; in particular, extrasynaptic neuromodulatory interactions involving neuropeptides are widespread in all nervous systems, and these wireless interactions are critical to […]
The hippocampus as a small-world cognitive map
From the neurobiological traces of adverse prenatal exposure to clinical Intervention
Mechanisms of Brain Resilience in Neurodegeneration
Heterogeneity in the brain: lessons from theory and experiment
Abstract: Neurons in the brain are not identical: they show a wide variety of properties. Recently, we showed that this neural diversity itself is not static: it depends on for instance input characteristics and on neuromodulatory state. How does this heterogeneity influence the dynamics and information processing of neural networks? Is this a dial the […]