Aberration corrected microendoscopes for extended field-of-view deep brain imaging in benchtop and miniaturized two-photon microscopes

Abstract: Neural population dynamics in deep regions of the brain play fundamental roles in crucial brain functions, from decision making to the processing of sensory information. A fundamental prerequisite to understand how neuronal population dynamics in the deep brain control such important behavioral processes is to sample large neuronal networks with high and homogeneous spatial resolution […]

Emergent properties of memory networks with E-I assemblies

Abstract: Animals constantly sample information from the external world, and memorizing some of it is essential for adaptive behavior. Classical views suggest that memories are stored in assemblies of excitatory neurons and retrieved through attractor dynamics. However, increasing evidence indicates that during learning, groups of both excitatory (E) and inhibitory (I) neurons become strongly interconnected, […]

Other kinds of connectomes: wireless networks and behavioural states

Abstract: Efforts are ongoing to build and map synaptic wiring diagrams, or connectomes, to understand the neural basis of brain function. However, chemical synapses represent only one type of functionally important signalling interaction between neurons; in particular, extrasynaptic neuromodulatory interactions involving neuropeptides are widespread in all nervous systems, and these wireless interactions are critical to […]